Sudden Death in Epilepsy

Author: Claire M. Lathers
Publisher: CRC Press
ISBN: 9781439802236
Format: PDF, ePub
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Though it is one of the most common causes of death in epilepsy patients, SUDEP is still infrequently and even reluctantly named on autopsy reports. This under-reporting equates to a lack of attention and earnest investigation into the cause, predisposition, and prevention of SUDEP. There is as yet little effort to establish an actionable strategy in the mitigation of these potentially fatal arrhythmias. Expanding on the 1990 book Epilepsy and Sudden Death, edited by Lathers and Schraeder, Sudden Death in Epilepsy: Forensic and Clinical Issues reviews of the basic science of epilepsy as it relates to SUDEP. Clinical chapters study the sophisticated simultaneous ambulatory EKG and EEG telemetry and respiratory function monitoring of patients at risk for sudden death that will help identify cardiac, respiratory, and epileptogenic interactions involved. Chapters on animal models evaluate new data from studies that build on previously used models and emphasize that multiple models are needed to investigate the pathophysiology of SUDEP, to hypothesize about effective treatments, to develop pilot studies in persons with epilepsy, and to conduct confirmatory large-scale clinical trials. Contributions discuss the interaction between the central and peripheral autonomic nervous systems and the cardiopulmonary systems; proposed mechanistic factors in SUDEP; risk categories of arrhythmogenic, respiratory, and hypoxia related cardiac death; psychological, emotional, and stress related factors; the role of alcohol and drugs in seizures; and the potential mitigating properties of antiepileptic medication. Adopting a global, multidisciplinary focus to address the mystery of SUDEP, this important work provides clinicians, researchers, patients, and families with the knowledge to freely discuss the phenomenon and thereby discover the preventive treatment regimens to decrease the occurrence of SUDEP.

Sudden Unexpected Death in Epilepsy

Author: Claire M. Lathers
Publisher: CRC Press
ISBN: 1482223880
Format: PDF, Mobi
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Sudden Unexpected Death in Epilepsy: Mechanisms and New Methods for Analyzing Risks builds on earlier works focusing on the clinical problem of sudden unexpected death in epilepsy (SUDEP). This book presents a methodology for identifying and classifying clusters of risks that lead to SUDEP. Developed over the last two years, the SUDEP Classification System and Risk Factor Cluster ID method will help to address gaps in our knowledge about the causes and possible prevention of this tragic complication. Exploring the interactions among the central and peripheral autonomic nervous systems and the cardiopulmonary systems, the book includes case studies of SUDEP, definite or probable, as well as near miss cases. It discusses how neurologists, emergency room physicians, and attending physicians can identify individuals at possible risk for SUDEP and lessen the chance of occurrence. Top medical professionals in the field detail the development of an international database of human cases and animal models of SUDEP and suggest how medical examiner and coroner offices can strengthen the database by providing information about incidences of SUDEP. In addition, the book describes related clinical and animal studies needed to classify risk factors for SUDEP victims. Understanding the risk factors and mechanisms underlying SUDEP will facilitate collaborative research in the laboratory, hospital, and clinic and lead to improved effectiveness of SUDEP prevention strategies.

Epilepsy Across the Spectrum

Author: Committee on the Public Health Dimensions of the Epilepsies
Publisher: National Academies Press
ISBN: 0309255074
Format: PDF, Kindle
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Although epilepsy is one of the nation's most common neurological disorders, public understanding of it is limited. Many people do not know the causes of epilepsy or what they should do if they see someone having a seizure. Epilepsy is a complex spectrum of disorders that affects an estimated 2.2 million Americans in a variety of ways, and is characterized by unpredictable seizures that differ in type, cause, and severity. Yet living with epilepsy is about much more than just seizures; the disorder is often defined in practical terms, such as challenges in school, uncertainties about social situations and employment, limitations on driving, and questions about independent living. The Institute of Medicine was asked to examine the public health dimensions of the epilepsies, focusing on public health surveillance and data collection; population and public health research; health policy, health care, and human services; and education for people with the disorder and their families, health care providers, and the public. In Epilepsy Across the Spectrum, the IOM makes recommendations ranging from the expansion of collaborative epilepsy surveillance efforts, to the coordination of public awareness efforts, to the engagement of people with epilepsy and their families in education, dissemination, and advocacy for improved care and services. Taking action across multiple dimensions will improve the lives of people with epilepsy and their families. The realistic, feasible, and action-oriented recommendations in this report can help enable short- and long-term improvements for people with epilepsy. For all epilepsy organizations and advocates, local, state, and federal agencies, researchers, health care professionals, people with epilepsy, as well as the public, Epilepsy Across the Spectrum is an essential resource.

Handbook of Forensic Medicine

Author: Burkhard Madea
Publisher: John Wiley & Sons
ISBN: 1118570626
Format: PDF
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Forensic Medicine encompasses all areas in which medicine and law interact. This book covers diverse aspects of forensic medicine including forensic pathology, traumatology and violent death, sudden and unexpected death, clinical forensic medicine, toxicology, traffic medicine, identification, haemogenetics and medical law. A knowledge of all these subdisciplines is necessary in order to solve routine as well as more unusual cases. Taking a comprehensive approach the book m.oves beyond a focus on forensic pathology to include clinical forensic medicine and forensic toxicology. All aspects of forensic medicine are covered to meet the specialist needs of daily casework. Aspects of routine analysis and quality control are addressed in each chapter. The book provides coverage of the latest developments in forensic molecular biology, forensic toxicology, molecular pathology and immunohistochemistry. A must-have reference for every specialist in the field this book is set to become the bench-mark for the international forensic medical community.

Encyclopedia of Forensic and Legal Medicine

Author:
Publisher: Academic Press
ISBN: 0128000554
Format: PDF, ePub
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Encyclopedia of Forensic and Legal Medicine, Volumes 1-4, Second Edition is a pioneering four volume encyclopedia compiled by an international team of forensic specialists who explore the relationship between law, medicine, and science in the study of forensics. This important work includes over three hundred state-of-the-art chapters, with articles covering crime-solving techniques such as autopsies, ballistics, fingerprinting, hair and fiber analysis, and the sophisticated procedures associated with terrorism investigations, forensic chemistry, DNA, and immunoassays. Available online, and in four printed volumes, the encyclopedia is an essential reference for any practitioner in a forensic, medical, healthcare, legal, judicial, or investigative field looking for easily accessible and authoritative overviews on a wide range of topics. Chapters have been arranged in alphabetical order, and are written in a clear-and-concise manner, with definitions provided in the case of obscure terms and information supplemented with pictures, tables, and diagrams. Each topic includes cross-referencing to related articles and case studies where further explanation is required, along with references to external sources for further reading. Brings together all appropriate aspects of forensic medicine and legal medicine Contains color figures, sample forms, and other materials that the reader can adapt for their own practice Also available in an on-line version which provides numerous additional reference and research tools, additional multimedia, and powerful search functions Each topic includes cross-referencing to related articles and case studies where further explanation is required, along with references to external sources for further reading

Life Threatening Effects of Antipsychotic Drugs

Author: Peter Manu
Publisher: Academic Press
ISBN: 0128033908
Format: PDF, ePub, Mobi
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Life-Threatening Effects of Antipsychotic Drugs describes in detail more than 20 life-threatening effects associated with antipsychotics, presents the best available data on their incidence and case fatality, and gives comprehensive advice on diagnosis, management and preventive strategies. In addition, the book discusses the benefit of antipsychotic medication in a range of therapeutic indications, and demonstrates the gain in life-expectancy associated with clozapine use in severe mental illness despite its serious, potentially life-threatening adverse effects. Covers cardiovascular, neurological, muscular, hematological, gastrointestinal, autonomic and metabolic effects Gives advice on risk factors, confounding diagnoses and measures to minimise seriousness Discusses clozapine rechallenge after each of its serious adverse reactions Makes suggestions for optimum management of somatic disease in those with severe mental illness, to improve life-expectancy Includes data on post-mortem considerations

Knight s Forensic Pathology Fourth Edition

Author: Pekka Saukko
Publisher: CRC Press
ISBN: 1444165089
Format: PDF
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The fourth edition of Knight's Forensic Pathology continues to be the definitive international resource for those in training and in practice, covering all aspects of the medico-legal autopsy, including the cause and time of death, interpretation of wounds and every other facet of the investigation of a fatality. The contents are intended to lead the pathologist – and in some countries, the non-pathologist – through the procedures needed in the examination of a body found under obscure, suspicious or even criminal circumstances. Although police procedures and the habits of pathologists may vary from country to country, the philosophy and techniques presented in this book offer a guide to good practices that can be modified according to local circumstances. In this new edition the text has been thoroughly updated and is complemented by the addition of over 200 new colour illustrations. It maintains the praised tradition of clarity and readability established since Prof. Bernard Knight’s first edition was published in 1991, with an emphasis on the practical application of knowledge and research findings and the avoidance of over-interpretation.

Medicolegal Neuropathology

Author: David Dolinak
Publisher: CRC Press
ISBN: 1420040308
Format: PDF, Docs
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Medicolegal Neuropathology: A Color Atlas uniquely demonstrates and explains many neuropathologic findings in a way that will aid investigators of sudden and unexpected death integrate their own findings into the total case context. With helpful tips and reminders, as well as over 500 bold, colorful photographs, this well-organized resource helps you quickly recognize, document, and understand the diverse realm of neuropathological findings waiting to be discovered at autopsy. Organized in a case-oriented format, Medicolegal Neuropathology: A Color Atlas shows you: Many large external and internal color photographs Proper methods of documenting and interpreting pathologic findings Methods of performing specialized autopsy procedures Techniques for proper sampling and preparation of tissues for microscopic examination Important traumatic and nontraumatic findings and their significance A refresher course on normal anatomical structures

Epilepsy

Author: Jong Rho
Publisher: CRC Press
ISBN: 1420085603
Format: PDF, Docs
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Epilepsy has afflicted humankind throughout recorded history; yet, it is only in the last half-century, that significant progress has been made in our basic understanding of the epileptic brain. Pivotal advances in drug development and surgical techniques, as well as the emergence of innovative approaches such as electrical stimulation of the nervous system, have led to a substantial reduction in the morbidity and mortality of patients with epilepsy. At the same time, remarkable developments in neuroscience have enhanced our understanding of brain structure and function. Epilepsy: Mechanisms, Models, and Translational Perspectives incorporates new translational advances that bring epilepsy therapies from the laboratory bench to the bedside and back again. It brings together the work of more than 70 of the field’s most respected and cutting-edge researchers and clinicians. In 24 chapters, this extraordinarily comprehensive and current work: Offers an overview of the basic anatomic and functional substrates of seizure genesis and considers novel pathogenic concepts that have both emerged and been validated experimentally Examines antiepileptic drug therapy, including the latest on molecular targets Looks at the state of surgical treatments for epilepsy and discusses advances in the fields of structural and functional neuroimaging Reviews the variety of nontraditional therapeutic options, such as the ketogenic diet, the vagus nerve stimulator, immunomodulators, neurosteroids, herbs, and botanicals Investigates neuroendocrine, hormonal, and biobehavioral factors that influence seizure susceptibility—information that can be incorporated into the design of treatment algorithms on an individualized basis Provides a glimpse of what future epilepsy therapies might look like, from novel mechanisms of drug delivery to gene and stem-cell therapies for epilepsy to seizure detection methods, to the ultimate goal of disease prevention. The idea for this book was inspired by the editors’ collective desire to promote bridging of the so-called translational divide—that is, covering innovative treatment strategies based on scientific principles that have yet to be tested rigorously in the clinical setting, but yet may provide practitioners with new and promising approaches toward epilepsy therapeutics.

Quick Reference to Child and Adolescent Forensics

Author: Mary E. Muscari, PhD, MSCr, CPNP, PMHCNS-BC, AFN-BC
Publisher: Springer Publishing Company
ISBN: 9780826124180
Format: PDF, Mobi
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"Quick Reference to Child and Adolescent Forensics most assuredly needs to have a prominent place in the library of any forensic nurse or health professional and have very worn pages from its frequent use." --On the Edge, Newsletter of the International Association of Forensic Nurses "Muscari and Brown have written a great reference work for anyone who works with either child or teen victims or perpetrators of violent crime...Highly recommended." --Choice "This is a comprehensive guide to all forensic aspects of the treatment of children and teens, important to all health care providers who will encounter young patients...Highly recommended." --Choice "Drs. Muscari and Brown have synthesized the key information on forensics pediatrics and produced a 'must read' text that needs to be on every person's bookshelf." --Ann Wolbert Burgess, DNSc, APRN, BC Professor of Psychiatric Nursing, Boston College Health care practitioners frequently work with victims of child abuse, sexual assault, and juvenile offenders, but often lack the education and resources they need to deal with the everyday forensic issues of pediatric practice. This quick guide provides current information that assists pediatric practitioners with the prevention, identification, and management of pediatric victims and offenders. The book describes the general principles of forensics and its implications in pediatric practice, including the cycle, continuum, and cultural aspects of violence. It also serves as a guide to conducting the forensic assessment and recording the legal documentation, collecting evidence, navigating the criminal and family justice systems, and producing expert witness testimony. The authors clearly define the role of the pediatric provider working with children who witness violence at home, in the community, and in the media. Key topics: How to detect abusive parents as well as abused children The effects of victimization of children by abusive, absent, or incarcerated parents Delinquency and juvenile justice systems-with insight into bullying, school violence, arson, gang membership, juvenile sex offending, and dating violence Unnatural pediatric deaths, such as sudden unexpected infant and child death, accidents, homicides, and suicides Practicing emergency room nurses, pediatric critical care nurses, nurse practitioners, and student practitioners will find this book to be an essential reference guide for managing and understanding pediatric forensics.