Estrogen Action Selective Estrogen Receptor Modulators and Women s Health

Author: V Craig Jordan
Publisher: World Scientific
ISBN: 1848169590
Format: PDF, Docs
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This volume presents the evolution of the authors' ideas about estrogen action and its modulation by a new group of drugs called SERMs (Selective Estrogen Receptor Modulators). The pioneering SERMs — tamoxifen and raloxifene — are known to have saved the lives of millions of women around the world and improved the health of millions more. Estrogen is the central hormone of women's health and reproduction. The book is a journey through 40 years of discovery and success in advancing women's health, with the prospect of improved innovation through medicinal chemistry for the future. Contents:A Century of Deciphering the Control Mechanisms of Estrogen Action in Breast Cancer: The Origins of Targeted Therapy and Chemoprevention (V Craig Jordan)Diethylstilbestrol: A Tragedy in Reproductive Endocrinology But a Pioneering Cancer Treatment (Joan Lewis-Wambi and V Craig Jordan)Oral Contraceptives and Women's Health (V Daniel Castracane and V Craig Jordan)Hormone Replacement Therapy and Women's Health (Jennifer Eng-Wong, Ifeyinwa Obiorah and V Craig Jordan)Induction of Ovulation by Nonsteroidal Antiestrogens (Ifeyinwa Obiorah and V Craig Jordan)Clues About Estrogen and Antiestrogen Action from X-Ray Crystallography (Geoffrey L Greene and V Craig Jordan)Coregulators and Their Role in Selective Estrogen Receptor Modulator Action (Christopher D Chien, Anton Wellstein and Anna Riegel)Role of Estrogen in Familial Breast Cancer (Eliot Rosen and Claudine Isaacs)Advances with Aromatase Inhibitors (Saranya Chumsri, Ting Bao, Gauri Sabnis and Angela Brodie)Adjuvant Antihormone Therapy (Anthony Howell and V Craig Jordan)Pharmacogenomics of Tamoxifen (Hiltrud B Brauch and V Craig Jordan)Antihormone Drug Resistance (Robert Clarke and V Craig Jordan)Novel Selective Estrogen Receptor Modulators (Surojeet Sengupta and V Craig Jordan)Endocrine Prevention of Breast Cancer (Trevor J Powles, Russell E McDaniel and V Craig Jordan)Selective Androgen Receptor Modulators as Improved Androgen Therapy for Women (Christopher C Coss and James T Dalton)An Emerging Principle: Selective Nuclear Receptor Modulators (Ping Fan and V Craig Jordan) Readership: Clinicians, biological faculty, informed patients, scientists and students in biology and medicine, healthcare and medical professionals, breast cancer survivors. Keywords:Estrogen;Women's Health;SERMs;Breast Cancer;Tamoxifen;Raloxifene;DESKey Features:A unique easy-to-read book for clinicians, biological faculty, informed patients, scientists and medical professionalsFocuses on the evolution of estrogen action in women's health and changes in healthcare through scientific researchA concise summary of progressNo other competing titles of the same caliberWritten by the pioneers in the field

Estrogen Action Selective Estrogen Receptor Modulators and Women s Health

Author: V. Craig Jordan
Publisher:
ISBN: 9781848169579
Format: PDF, ePub, Mobi
Download and Read
This volume presents the evolution of the authors' ideas about estrogen action and its modulation by a new group of drugs called SERMs (Selective Estrogen Receptor Modulators). The pioneering SERMs — tamoxifen and raloxifene — are known to have saved the lives of millions of women around the world and improved the health of millions more. Estrogen is the central hormone of women's health and reproduction. The book is a journey through 40 years of discovery and success in advancing women's health, with the prospect of improved innovation through medicinal chemistry for the future.

Gonadotropins From Bench Side to Bedside

Author: Rajendra T. Kumar
Publisher: Academic Press
ISBN: 0128012668
Format: PDF, ePub
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Gonadotropins: From Bench Side to Bedside, the latest volume in the Progress in Molecular Biology and Translational Science series, focuses on all aspects of gonadotropins, from research to treatment. Contains contributions from leading authorities on the topic Publishes cutting-edge reviews in molecular biology Informs and updates on all the latest developments available regarding the research of gonadotropins

Nuclear Receptors as Drug Targets

Author: Eckhard Ottow
Publisher: John Wiley & Sons
ISBN: 3527623302
Format: PDF, Kindle
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Edited by two experts working at the pioneering pharmaceutical company and major global player in hormone-derived drugs, this handbook and reference systematically treats the drug development aspects of all human nuclear receptors, including recently characterized receptors such as PPAR, FXR and LXR. Authors from leading pharmaceutical companies around the world present examples and real-life data from their own work.

Tamoxifen

Author: Philipp Y. Maximov
Publisher: Springer Science & Business Media
ISBN: 3034806647
Format: PDF, Docs
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Tamoxifen is a pioneering medicine for the treatment and prevention of breast cancer. It is the first drug targeted therapy in cancer to be successful. Tamoxifen targets the tumor estrogen receptor. The therapy is known to have saved the lives of millions of women over the past 40 years. This monograph, written by V. Craig Jordan - known as the “father of tamoxifen” - and his Tamoxifen Team at the Georgetown University Washington DC, illustrates the journey of this milestone in medicine. It includes a personal interview with V. Craig Jordan about his four decades of discovery in breast cancer research and treatment. V. Craig Jordan was there for the birth of tamoxifen as he is credited for reinventing a “failed morning after contraceptive” to become the “gold standard” for the treatment of breast cancer. He contributed to every aspect of tamoxifen application in therapeutics and all aspects of tamoxifen’s pharmacology. He discovered the selective estrogen receptor modulators (SERMs) and explored the new biology of estrogen-induced apoptosis.

Endocrine Therapy in Breast Cancer

Author: William R. Miller
Publisher: CRC Press
ISBN: 0203909836
Format: PDF, ePub, Docs
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This reference evaluates and describes the latest strategies for hormone suppression and blockade in the management of early and advanced stage breast cancer and explores the effects of tamoxifen, selective estrogen receptor modulators (SERMs), aromatase inhibitors, and their combination on both breast cancers and normal tissues. Endocrine Therapy in Breast Cancer details modern techniques for molecular profiling, monitoring, and targeting offers methods to identify high-risk groups evaluates molecular biomarkers in breast cancer assessment examines the potential toxicity of estrogen receptor (ER)-directed endocrine therapy investigates the development of endocrine resistance discusses neoadjuvant and preoperative approaches in patient care reviews mechanisms that lead to estrogen-independent phenotypes Surveying the medical, surgical, and pathological aspects of endocrine therapy, as well as future research opportunities, Endocrine Therapy in Breast Cancer is a concise and in-depth manual for medical, surgical, and radiation oncologists; endocrinologists; gynecologists; obstetricians; pharmacologists; family physicians; reproductive biologists; epidemiologists; and medical school students.

The Estrogen Fix

Author: Mache Seibel
Publisher: Rodale Books
ISBN: 1635651964
Format: PDF, ePub, Docs
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With groundbreaking research and an exciting new theory that will change the way women look at hormone replacement therapy for years of substantially improved health, happiness, and quality of life, The Estrogen Fix is a must-have book for every woman over 40. Dr. Mache Seibel, one of the leading doctors in women's health and menopause, proves that every woman has an ideal time to more safely begin estrogen replacement. When administered at this time, referred to as "the estrogen window," estrogen can lower your risk for breast cancer, heart disease, Alzheimer's, diabetes, osteoporosis, and more while minimizing your symptoms. Offering hope, expertise, and concrete solutions to a rectifiable problem, The Estrogen Fix is the definitive book on hormonal health for women. If estrogen has you confused or worried, if you are toughing it out because it seems too complicated to figure it out, if your doctors are reluctant to treat you and your symptoms are making your life a challenge, this book is for you.

The Well Woman Visit

Author: David Chelmow
Publisher: Cambridge University Press
ISBN: 1316509982
Format: PDF, Docs
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This accessible text expands on the recommendations of the American College of Obstetricians and Gynecologists' Well Woman Task Force (WWTF) to provide a practical guide to conducting a successful Well-Woman visit. Background chapters summarize the history of the WWTF and rationale and evidence supporting periodic health visits, explain the principles of early diagnosis and prevention, and offer advice on the practical side of conducting a visit, including considerations for special populations. Chapters detail each component of the visit, first explaining the scope of a problem, the rationale for screening or prevention, and the factors that alter a screening. The WWTF recommendations are then summarized and advice is offered on how to apply them. Case studies and advice on how to identify and assess new guidelines are also provided, ensuring providers are well-equipped to offer efficient and effective care.

Resistance to Aromatase Inhibitors in Breast Cancer

Author: Alexey Larionov
Publisher: Springer
ISBN: 3319179721
Format: PDF, Docs
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Aromatase Inhibitors (AIs) treat postmenopausal estrogen receptor positive tumours, which constitute the majority of breast cancer patients. This comprehensive volume brings together the current knowledge from different relevant areas, including molecular mechanisms and translational aspects of drug resistance in AIs. Topics covered include research, experimental , and clinical data specifically focused on AI resistance in breast cancer. The volume will include three sections. The first section covers general knowledge about aromatase inhibitors, including regulation of aromatase genes, and structure and function of aromatase protein. The second section provides the detailed mechanisms of resistance to AIs, while the third section explores prediction of resistance and potential strategies to overcome resistance. Breast cancer is the most common female cancer and AIs significantly improve treatments outcomes compatibly to previously used endocrine treatments. However 10-15% of post-operative patients develop a relapse during adjuvant treatment with AIs; about 25-50% of the patients do not respond to AIs in neo-adjuvant or metastatic setting, and the majority of metastatic patients who initially respond develop resistance within 3 years. There is an important need to understand these mechanisms of resistance in order to develop methods of preventing or overcoming the resistance to AIs, which will ensure a more successful outcome in treating breast cancer.

Handbook of Diet and Nutrition in the Menstrual Cycle Periconception and Fertility

Author: Caroline J. Hollins-Martin
Publisher: Wageningen Academic Publishers
ISBN: 9086862128
Format: PDF, ePub, Mobi
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The reproductive cycle in women is complex and can be considered to begin with epigenetic programming and ending with menopause. Intervening steps involve a variety of processes, including the cellular development of the sex organs, menarche, episodic endocrine cycles, menstruation, ovulation and conception. These processes can be influenced by diet and nutrition and vice versa. Body composition has an impact on the menstrual cycle and periconception and these factors in turn also influence body composition. Similarly, either food deprivation, dietary excess or obesity can result in marked changes in the menstrual cycle with a concomitant effect on fertility. This handbook is the first scientific source that provides a comprehensive overview of the relationship of diet and nutrition with puberty, menarche and menstrual cycle, conception and fertility and infertility. The handbook of diet and nutrition in the menstrual cycle, conception and fertility will benefit dieticians, nutritionists, gynaecologists, endocrinologists, obstetricians, paediatricians and those concerned with women's health in general.